Detalhe da pesquisa
1.
An Early Treatment With BKI-1748 Exhibits Full Protection Against Abortion and Congenital Infection in Sheep Experimentally Infected With Toxoplasma gondii.
J Infect Dis
; 229(2): 558-566, 2024 Feb 14.
Artigo
Inglês
| MEDLINE | ID: mdl-37889572
2.
Comparison of Toxicities among Different Bumped Kinase Inhibitor Analogs for Treatment of Cryptosporidiosis.
Antimicrob Agents Chemother
; 67(4): e0142522, 2023 04 18.
Artigo
Inglês
| MEDLINE | ID: mdl-36920244
3.
Appraisal of Fungus-Derived Xanthoquinodins as Broad-Spectrum Anti-Infectives Targeting Phylogenetically Diverse Human Pathogens.
J Nat Prod
; 86(6): 1596-1605, 2023 06 23.
Artigo
Inglês
| MEDLINE | ID: mdl-37276438
4.
Repurposing the Kinase Inhibitor Mavelertinib for Giardiasis Therapy.
Antimicrob Agents Chemother
; 66(7): e0001722, 2022 07 19.
Artigo
Inglês
| MEDLINE | ID: mdl-35703552
5.
Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.
Proc Natl Acad Sci U S A
; 116(14): 7015-7020, 2019 04 02.
Artigo
Inglês
| MEDLINE | ID: mdl-30894487
6.
Taming the Boys for Global Good: Contraceptive Strategy to Stop Malaria Transmission.
Molecules
; 25(12)2020 Jun 16.
Artigo
Inglês
| MEDLINE | ID: mdl-32560085
7.
P-Glycoprotein-Mediated Efflux Reduces the In Vivo Efficacy of a Therapeutic Targeting the Gastrointestinal Parasite Cryptosporidium.
J Infect Dis
; 220(7): 1188-1198, 2019 08 30.
Artigo
Inglês
| MEDLINE | ID: mdl-31180118
8.
Pharmacokinetics and In Vivo Efficacy of Pyrazolopyrimidine, Pyrrolopyrimidine, and 5-Aminopyrazole-4-Carboxamide Bumped Kinase Inhibitors against Toxoplasmosis.
J Infect Dis
; 219(9): 1464-1473, 2019 04 16.
Artigo
Inglês
| MEDLINE | ID: mdl-30423128
9.
Treatment with Bumped Kinase Inhibitor 1294 Is Safe and Leads to Significant Protection against Abortion and Vertical Transmission in Sheep Experimentally Infected with Toxoplasma gondii during Pregnancy.
Antimicrob Agents Chemother
; 63(7)2019 07.
Artigo
Inglês
| MEDLINE | ID: mdl-31061151
10.
Optimization of Methionyl tRNA-Synthetase Inhibitors for Treatment of Cryptosporidium Infection.
Antimicrob Agents Chemother
; 63(4)2019 04.
Artigo
Inglês
| MEDLINE | ID: mdl-30745384
11.
Toxoplasma Calcium-Dependent Protein Kinase 1 Inhibitors: Probing Activity and Resistance Using Cellular Thermal Shift Assays.
Antimicrob Agents Chemother
; 62(6)2018 06.
Artigo
Inglês
| MEDLINE | ID: mdl-29555627
12.
Therapeutic Efficacy of Bumped Kinase Inhibitor 1369 in a Pig Model of Acute Diarrhea Caused by Cryptosporidium hominis.
Antimicrob Agents Chemother
; 62(7)2018 07.
Artigo
Inglês
| MEDLINE | ID: mdl-29661877
13.
Necessity of Bumped Kinase Inhibitor Gastrointestinal Exposure in Treating Cryptosporidium Infection.
J Infect Dis
; 216(1): 55-63, 2017 07 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28541457
14.
Bumped-Kinase Inhibitors for Cryptosporidiosis Therapy.
J Infect Dis
; 215(8): 1275-1284, 2017 04 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28329187
15.
5-Aminopyrazole-4-Carboxamide-Based Compounds Prevent the Growth of Cryptosporidium parvum.
Antimicrob Agents Chemother
; 61(8)2017 08.
Artigo
Inglês
| MEDLINE | ID: mdl-28533246
16.
Development of a murine vertical transmission model for Toxoplasma gondii oocyst infection and studies on the efficacy of bumped kinase inhibitor (BKI)-1294 and the naphthoquinone buparvaquone against congenital toxoplasmosis.
J Antimicrob Chemother
; 72(8): 2334-2341, 2017 08 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28486633
17.
Discovery of N-(2-aminoethyl)-N-benzyloxyphenyl benzamides: New potent Trypanosoma brucei inhibitors.
Bioorg Med Chem
; 25(5): 1571-1584, 2017 03 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28187957
18.
Extended-spectrum antiprotozoal bumped kinase inhibitors: A review.
Exp Parasitol
; 180: 71-83, 2017 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-28065755
19.
A Novel Calcium-Dependent Kinase Inhibitor, Bumped Kinase Inhibitor 1517, Cures Cryptosporidiosis in Immunosuppressed Mice.
J Infect Dis
; 214(12): 1850-1855, 2016 Dec 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27738055
20.
Novel Bumped Kinase Inhibitors Are Safe and Effective Therapeutics in the Calf Clinical Model for Cryptosporidiosis.
J Infect Dis
; 214(12): 1856-1864, 2016 Dec 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27923949